The role of retrotransposable elements in ageing and age-associated diseases
The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …
the activity of transposable elements (transposons). Transposons are mobile genetic …
A field guide to eukaryotic transposable elements
JN Wells, C Feschotte - Annual review of genetics, 2020 - annualreviews.org
Transposable elements (TEs) are mobile DNA sequences that propagate within genomes.
Through diverse invasion strategies, TEs have come to occupy a substantial fraction of …
Through diverse invasion strategies, TEs have come to occupy a substantial fraction of …
Haplotype-resolved diverse human genomes and integrated analysis of structural variation
INTRODUCTION The characterization of the full spectrum of genetic variation is critical to
understanding human health and disease. Recent technological advances have made it …
understanding human health and disease. Recent technological advances have made it …
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues
L Zhang, A Richards, MI Barrasa… - Proceedings of the …, 2021 - National Acad Sciences
Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
RNA and recurrence of PCR-positive tests have been widely reported in patients after …
RNA and recurrence of PCR-positive tests have been widely reported in patients after …
Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome
Organization of the genome into euchromatin and heterochromatin appears to be
evolutionarily conserved and relatively stable during lineage differentiation. In an effort to …
evolutionarily conserved and relatively stable during lineage differentiation. In an effort to …
Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites
CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology
and entered the clinical world for targeted gene therapy. Identifying DNA modifications …
and entered the clinical world for targeted gene therapy. Identifying DNA modifications …
Template and target-site recognition by human LINE-1 in retrotransposition
The long interspersed element-1 (LINE-1, hereafter L1) retrotransposon has generated
nearly one-third of the human genome and serves as an active source of genetic diversity …
nearly one-third of the human genome and serves as an active source of genetic diversity …
Transposable elements, inflammation, and neurological disease
Transposable Elements (TE) are mobile DNA elements that can replicate and insert
themselves into different locations within the host genome. Their propensity to self …
themselves into different locations within the host genome. Their propensity to self …
Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements
In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3
lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome …
lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome …
LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities
C Mendez-Dorantes, KH Burns - Genes & development, 2023 - genesdev.cshlp.org
Abstract Long interspersed element 1 (LINE-1) is the only protein-coding transposon that is
active in humans. LINE-1 propagates in the genome using RNA intermediates via …
active in humans. LINE-1 propagates in the genome using RNA intermediates via …