[HTML][HTML] Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates
Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …
IgG antibodies to endothelial protein C receptor-binding cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are …
L Turner, T Lavstsen, BP Mmbando… - Infection and …, 2015 - Am Soc Microbiol
Severe malaria syndromes are precipitated by Plasmodium falciparum parasites binding to
endothelial receptors on the vascular lining. This binding is mediated by members of the …
endothelial receptors on the vascular lining. This binding is mediated by members of the …
[HTML][HTML] Immunisation with Recombinant PfEMP1 Domains Elicits Functional Rosette-Inhibiting and Phagocytosis-Inducing Antibodies to Plasmodium falciparum
Background Rosetting is a Plasmodium falciparum virulence factor implicated in the
pathogenesis of life-threatening malaria. Rosetting occurs when parasite–derived P …
pathogenesis of life-threatening malaria. Rosetting occurs when parasite–derived P …
[HTML][HTML] Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a …
Background The factors involved in the progression from Plasmodium falciparum infection to
severe malaria (SM) are still incompletely understood. Altered antibody and cellular …
severe malaria (SM) are still incompletely understood. Altered antibody and cellular …
Malaria evolution in South Asia: knowledge for control and elimination
The study of malaria parasites on the Indian subcontinent should help us understand
unexpected disease outbreaks and unpredictable disease presentations from Plasmodium …
unexpected disease outbreaks and unpredictable disease presentations from Plasmodium …
Improved Pregnancy Outcomes in Women Exposed to Malaria With High Antibody Levels Against Plasmodium falciparum
Abstract Background. Antibodies against VAR2CSA, the Plasmodium falciparum variant
surface antigen that binds placental chondroitin sulfate A, have been suggested to mediate …
surface antigen that binds placental chondroitin sulfate A, have been suggested to mediate …
[HTML][HTML] Impact of the RTS, S malaria vaccine candidate on naturally acquired antibody responses to multiple asexual blood stage antigens
JJ Campo, C Dobaño, J Sacarlal, C Guinovart… - PloS one, 2011 - journals.plos.org
Background Partial protective efficacy lasting up to 43 months after vaccination with the RTS,
S malaria vaccine has been reported in one cohort (C1) of a Phase IIb trial in Mozambique …
S malaria vaccine has been reported in one cohort (C1) of a Phase IIb trial in Mozambique …
[HTML][HTML] Cytokine and Antibody Responses to Plasmodium falciparum in Naïve Individuals during a First Malaria Episode: Effect of Age and Malaria Exposure
Age-and exposure-dependent immune responses during a malaria episode may be key to
understanding the role of these factors in the acquisition of immunity to malaria …
understanding the role of these factors in the acquisition of immunity to malaria …
Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure
A Valmaseda, E Macete, A Nhabomba… - Clinical Infectious …, 2018 - academic.oup.com
Background A main criterion to identify malaria vaccine candidates is the proof that acquired
immunity against them is associated with protection from disease. The age of the studied …
immunity against them is associated with protection from disease. The age of the studied …
[HTML][HTML] Allelic Diversity of the Plasmodium falciparum Erythrocyte Membrane Protein 1 Entails Variant-Specific Red Cell Surface Epitopes
I Vigan-Womas, M Guillotte, A Juillerat, C Vallieres… - PloS one, 2011 - journals.plos.org
The clonally variant Plasmodium falciparum PfEMP1 adhesin is a virulence factor and a
prime target of humoral immunity. It is encoded by a repertoire of functionally differentiated …
prime target of humoral immunity. It is encoded by a repertoire of functionally differentiated …