Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …

ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …

The Ets family of transcription factors characterized by an evolutionarily-conserved DNA-
binding domain regulates expression of a variety of viral and cellular genes by binding to a …

Fos and Jun family proteins regulate the expression of a myriad of genes in a variety of
tissues and cell types. This functional versatility emerges from their interactions with related …

The p16INK4a cyclin-dependent kinase inhibitor is implicated in replicative senescence, the
state of permanent growth arrest provoked by cumulative cell divisions or as a response to …

The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a
unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled …

Hematopoietic transcription factors are essential for specifying cell fates; however, the
function of cytokines in such developmental decisions is unresolved. We demonstrate here …

The transcription factors that regulate endothelial cell development have been a focus of
active research for several years, and many players in the endothelial transcriptional …

The three ternary complex factors (TCFs) Elk-1, Net and Sap-1 form a subfamily of the E
twenty-six (Ets) domain transcription factors. Their characteristic property is the ability to form …

Ewing's sarcoma is a highly aggressive bone and soft tissue tumor of children and young
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …