Cocrystals and salts of milrinone with fluoro coformers: improving drug dissolution and diffusion and calculating normalized diffusion for pharmaceutical cocrystals
Milrinone (MRN) is a second-generation bipyridine phosphodiesterase inhibitor that
improves cardiac function and peripheral vasodilation in acute decongested heart failure …
improves cardiac function and peripheral vasodilation in acute decongested heart failure …
A Perspective on the Permeability of Cocrystals/Organic Salts of Oral Drugs
According to the BCS classification system, the differentiation of drugs is based on two
essential parameters of solubility and permeability, meaning the latter is as pivotal as the …
essential parameters of solubility and permeability, meaning the latter is as pivotal as the …
Colorful Prothionamide Salt Forms with Enhancement in Water Solubility and Dissolution Behavior
WJ Ji, JY Jiang, M Hong, B Zhu, GB Ren… - Crystal Growth & …, 2023 - ACS Publications
Prothionamide (PRT) is used as an alternative to some first-line drugs in the treatment of
multi drug-resistant tuberculosis. Suffering from its extremely low water solubility and …
multi drug-resistant tuberculosis. Suffering from its extremely low water solubility and …
Synthon Approach in Crystal Engineering to Modulate Physicochemical Properties in Organic Salts of Chlorpropamide
AM Menon, NN Sidhartha, I Shruti… - Molecular …, 2024 - ACS Publications
The formulation of drug with improved bioavailability is always challenging and
indispensable in the field of pharmaceutics. The control of intermolecular interactions via …
indispensable in the field of pharmaceutics. The control of intermolecular interactions via …
Novel Pharmaceutical Cocrystal of Voxelotor, a Hemoglobin Oxygen Affinity Modulator: Synthesis, Crystal Structure, and Physicochemical Properties
Voxelotor (VOX), a small-molecule BCS class-II drug, is used for the treatment of sickle cell
disease. The USFDA granted accelerated approval for this drug molecule in 2019 as a first …
disease. The USFDA granted accelerated approval for this drug molecule in 2019 as a first …
Enhanced Dissolution and Diffusion of Ribociclib by Salt Formation with Fluorobenzoic Acid Coformers
S Sangwan, B Swapna, AK Nangia - Crystal Growth & Design, 2024 - ACS Publications
Ribociclib (RBC) is an anticancer drug of poor aqueous solubility and low permeability. In
this study, we report the improvement in the physicochemical properties of RBC, such as …
this study, we report the improvement in the physicochemical properties of RBC, such as …
Strategy to Improve the Oral Pharmacokinetics of Cyclin-Dependent Kinase 4/6 Inhibitors: Enhancing Permeability and CYP450 Inhibition by a Natural Bioenhancer
Palbociclib and ribociclib an orally bioavailable, potent cyclin-dependent kinase 4/6
inhibitors, with low oral bioavailability due to substrate specificity towards CYP3A and P …
inhibitors, with low oral bioavailability due to substrate specificity towards CYP3A and P …
Molecular salts of pipemedic acid and crystal structure, spectral properties, and Hirshfeld surface analysis
JC Shwetha, A Sharma, KA Solomon - Journal of the Iranian Chemical …, 2023 - Springer
The research involves synthesizing 1: 1 salts of Pipemedic acid (PMA) with oxalic acid (OA),
salicylic acid (SA), and p-Toluene sulfonic monohydrate (BS) using a slow evaporation …
salicylic acid (SA), and p-Toluene sulfonic monohydrate (BS) using a slow evaporation …