Cys‐tematic modification: Cysteine is a versatile amino acid for selective chemical
modification of proteins. Both chemical and biological innovations made possible by …

Chemical modification of protein is an arduous but fruitful task. Many chemical methods
have been developed for such purpose by carefully balancing reactivity and selectivity. Now …

Selenium, originally described as a toxin, turns out to be a crucial trace element for life that
appears as selenocysteine and its dimer, selenocystine. From the point of view of drug …

In synthetic organic chemistry, the anti‐Markovnikov thiol− ene click (TEC) reaction has
emerged as a powerful and widely used approach to build carbon− sulfur (C− S) bonds …

Chemical modification of proteins is important for creating a myriad of engineered proteins
and for elucidating the function and dynamics of proteins in live cells. A wide variety of …

Synthetic methods for unsymmetrical disulfides are greatly needed owing to their
applications in drug discovery, linker chemistry, and materials sciences. In this study, a new …

Page Scheme S1 S2 Scheme S2 S2 Scheme S3 S2 General procedures S3 p-Nitrophenyl
2, 3, 4, 6-tetra-O-benzyl-1-thio-α-D-glucopyranoside 2 S5 General procedure for …

Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification.
Here, efficient protein CM has been demonstrated through biomimetic chemical access to …

Fifteen years ago, in 2001, the concept of “Reactive Sulfur Species” or RSS was advocated
as a working hypothesis. Since then various organic as well as inorganic RSS have …

Protein compatible. Olefin metathesis has emerged as a viable strategy for site‐selective
protein modification. This minireview traces its development from early peptide models and …