Botulinum toxin: State of the art
J Jankovic - Movement Disorders, 2017 - Wiley Online Library
Botulinun neurotoxin (BoNT) has emerged as one of the most multipurpose therapeutic
agents in modern medicine with more clinical applications than any other drug currently on …
agents in modern medicine with more clinical applications than any other drug currently on …
[HTML][HTML] Novel botulinum neurotoxins: Exploring underneath the iceberg tip
DA Tehran, M Pirazzini - Toxins, 2018 - mdpi.com
Botulinum neurotoxins (BoNTs), the etiological agents of botulism, are the deadliest toxins
known to humans. Yet, thanks to their biological and toxicological features, BoNTs have …
known to humans. Yet, thanks to their biological and toxicological features, BoNTs have …
Isolation and characterization of Hc-targeting chimeric heavy chain antibodies neutralizing botulinum neurotoxin type B
Y Jiang, R Wang, J Guo, K Cheng, L Chen… - Frontiers in …, 2024 - frontiersin.org
Background Botulinum neurotoxin (BoNT) produced by Clostridium botulinum is one of the
most potent known toxins. Moreover, BoNT is classified as one of the most important …
most potent known toxins. Moreover, BoNT is classified as one of the most important …
[HTML][HTML] A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype E subtypes
Human botulism is most commonly caused by botulinum neurotoxin (BoNT) serotypes A, B,
and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based …
and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based …
[HTML][HTML] Clostridial neurotoxins: Structure, function and implications to other bacterial toxins
Gram-positive bacteria are ancient organisms. Many bacteria, including Gram-positive
bacteria, produce toxins to manipulate the host, leading to various diseases. While the …
bacteria, produce toxins to manipulate the host, leading to various diseases. While the …
Crystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1
Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans,
comprising seven established serotypes termed BoNT/A–G encoded in two types of gene …
comprising seven established serotypes termed BoNT/A–G encoded in two types of gene …
[HTML][HTML] Variations in the botulinum neurotoxin binding domain and the potential for novel therapeutics
JR Davies, SM Liu, KR Acharya - Toxins, 2018 - mdpi.com
Botulinum neurotoxins (BoNTs) are categorised into immunologically distinct serotypes
BoNT/A to/G). Each serotype can also be further divided into subtypes based on differences …
BoNT/A to/G). Each serotype can also be further divided into subtypes based on differences …
Descriptive epidemiology of infant botulism in California: the first 40 years
MV Panditrao, HA Dabritz, NN Kazerouni… - The Journal of …, 2020 - Elsevier
Objective To ascertain the descriptive epidemiology of infant botulism, the flaccid paralysis
that results when neurotoxigenic Clostridium species produce botulinum toxin (BoNT) in the …
that results when neurotoxigenic Clostridium species produce botulinum toxin (BoNT) in the …
[HTML][HTML] The novel clostridial neurotoxin produced by strain IBCA10-7060 is immunologically equivalent to BoNT/HA
Background: Botulinum neurotoxins (BoNTs) comprise seven agreed-on serotypes, A
through G. In 2014, a novel chimeric neurotoxin produced by clostridial strain IBCA10-7060 …
through G. In 2014, a novel chimeric neurotoxin produced by clostridial strain IBCA10-7060 …
Substrate cleavage and duration of action of botulinum neurotoxin type FA (“H, HA”)
S Pellett, WH Tepp, G Lin, EA Johnson - Toxicon, 2018 - Elsevier
Botulinum neurotoxin (BoNT) type FA is the only known naturally occurring chimeric BoNT of
domains of BoNT/A and BoNT/F. BoNT/FA consists of an F5-like light chain (LC), a unique …
domains of BoNT/A and BoNT/F. BoNT/FA consists of an F5-like light chain (LC), a unique …