Lipolysis: cellular mechanisms for lipid mobilization from fat stores

GF Grabner, H Xie, M Schweiger, R Zechner - Nature metabolism, 2021 - nature.com
The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

P Morigny, J Boucher, P Arner, D Langin - Nature Reviews …, 2021 - nature.com
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Commensal Cutibacterium acnes induce epidermal lipid synthesis important for skin barrier function

S Almoughrabie, L Cau, K Cavagnero, AM O'Neill… - Science …, 2023 - science.org
Lipid synthesis is necessary for formation of epithelial barriers and homeostasis with
external microbes. An analysis of the response of human keratinocytes to several different …

Adipocyte regulation of insulin sensitivity and the risk of type 2 diabetes

A Santoro, BB Kahn - New England Journal of Medicine, 2023 - Mass Medical Soc
Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Lipid droplets and liver disease: from basic biology to clinical implications

NL Gluchowski, M Becuwe, TC Walther… - Nature reviews …, 2017 - nature.com
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …

Cytosolic lipolysis and lipophagy: two sides of the same coin

R Zechner, F Madeo, D Kratky - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

The regulation of fat metabolism during aerobic exercise

A Muscella, E Stefàno, P Lunetti, L Capobianco… - Biomolecules, 2020 - mdpi.com
Since the lipid profile is altered by physical activity, the study of lipid metabolism is a
remarkable element in understanding if and how physical activity affects the health of both …

Regulation of glucose and lipid metabolism in health and disease

L Chen, XW Chen, X Huang, BL Song, Y Wang… - Science China life …, 2019 - Springer
Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

Cardiomyopathy in obesity, insulin resistance and diabetes

M Nakamura, J Sadoshima - The Journal of physiology, 2020 - Wiley Online Library
The prevalence of obesity, insulin resistance and diabetes is increasing rapidly. Most
patients with these disorders have hypertriglyceridaemia and increased plasma levels of …

Lipid droplets in health and disease

G Onal, O Kutlu, D Gozuacik… - Lipids in health and …, 2017 - Springer
Lipids are essential building blocks synthesized by complex molecular pathways and
deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found …