Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …

Mitochondria are semi‐autonomous organelles of prokaryotic origin that are postulated to
have been acquired by eukaryotic cells through an early endosymbiotic event. Except for …

Aging has been associated with a progressive decline of proteostasis, but how this process
affects proteome composition remains largely unexplored. Here, we profiled more than …

The description of the non-equilibrium dynamics of isolated quantum many-body systems
within the framework of statistical mechanics is a fundamental open question. Conventional …

Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome
transit along a given mRNA can influence nascent chain folding, but the extent to which …

Protein aggregates are the hallmark of stressed and ageing cells, and characterize several
pathophysiological states,. Healthy metazoan cells effectively eliminate intracellular protein …

Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …

The timely production of functional proteins is of critical importance for the biological activity
of cells. To reach the functional state, newly synthesized polypeptides have to become …

The incidence and prevalence of cardiac diseases, which are the main cause of death
worldwide, are likely to increase because of population ageing. Prevailing theories about …