BRCA1 and BRCA2: different roles in a common pathway of genome protection
R Roy, J Chun, SN Powell - Nature Reviews Cancer, 2012 - nature.com
The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …
BRCA2, work in a common pathway of genome protection. However, the two proteins work …
53BP1: pro choice in DNA repair
M Zimmermann, T De Lange - Trends in cell biology, 2014 - cell.com
The DNA damage response factor 53BP1 functions at the intersection of two major double
strand break (DSB) repair pathways–promoting nonhomologous end-joining (NHEJ) and …
strand break (DSB) repair pathways–promoting nonhomologous end-joining (NHEJ) and …
[HTML][HTML] Cancer susceptibility and the functions of BRCA1 and BRCA2
AR Venkitaraman - Cell, 2002 - cell.com
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
Their ubiquitously expressed protein products are implicated in processes fundamental to all …
Their ubiquitously expressed protein products are implicated in processes fundamental to all …
Sensing and repairing DNA double-strand breaks
SP Jackson - Carcinogenesis, 2002 - academic.oup.com
The DNA double-strand break (DSB) is the principle cytotoxic lesion for ionizing radiation
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …
Chromosomal stability and the DNA double-stranded break connection
DC Van Gent, JHJ Hoeijmakers, R Kanaar - Nature Reviews Genetics, 2001 - nature.com
Genome stability is of primary importance for the survival and proper functioning of all
organisms. Double-stranded breaks in DNA are important threats to genome integrity …
organisms. Double-stranded breaks in DNA are important threats to genome integrity …
Cancer suppression by the chromosome custodians, BRCA1 and BRCA2
AR Venkitaraman - Science, 2014 - science.org
Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies,
most notably tumors of the breast and ovaries. The proteins encoded by these genes have …
most notably tumors of the breast and ovaries. The proteins encoded by these genes have …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
S Lipkowitz, AM Weissman - Nature Reviews Cancer, 2011 - nature.com
The ubiquitin-proteasome system has numerous crucial roles in physiology and
pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases …
pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases …
[HTML][HTML] BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function
BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase
family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a …
family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a …
Genetic steps of mammalian homologous repair with distinct mutagenic consequences
Repair of chromosomal breaks is essential for cellular viability, but misrepair generates
mutations and gross chromosomal rearrangements. We investigated the interrelationship …
mutations and gross chromosomal rearrangements. We investigated the interrelationship …