Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

In a T1D rat model, depressed sarcoplasmic reticulum function was reported by Penpargkul
et al4 in 1981. Subsequent studies in a T1D mouse model found a significant decrease in …

In recent years, diabetes mellitus has become an epidemic and now represents one of the
most prevalent disorders. Cardiovascular complications are the major cause of mortality and …

Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

Excessive feeding is associated with an increase in the incidence of chronic metabolic
diseases, such as obesity, insulin resistance, and type 2 diabetes. Metabolic disturbance …

The adipocyte-derived adipokine leptin exerts pleiotropic effects, which are essential for the
regulation of energy balance and cell metabolism, for controlling inflammatory and immune …

Increasing evidence has implicated the important role of mitochondrial pathology in diabetic
cardiomyopathy (DCM), while the underlying mechanism remains largely unclear. The aim …

Since diabetic cardiomyopathy was first reported four decades ago, substantial information
on its pathogenesis and clinical features has accumulated. In the heart, diabetes enhances …

Diabetes mellitus increases the risk of heart failure independently of underlying coronary
artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying …

Individuals with diabetes mellitus (DM) disclose a higher incidence and a poorer prognosis
of heart failure (HF) than non-diabetic people, even in the absence of other HF risk factors …