Targeted intracellular delivery of antibodies: the state of the art
A dominant area of antibody research is the extension of the use of this mighty experimental
and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and …
and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and …
Catalytic antibodies: Design, expression, and their applications in medicine
D Zhao, J Chen, X Hu, S Zhang - Applied Biochemistry and Biotechnology, 2023 - Springer
Catalytic antibodies made it feasible to develop new catalysts, which had previously been
the subject of research. Scientists have discovered natural antibodies that can hydrolyze …
the subject of research. Scientists have discovered natural antibodies that can hydrolyze …
Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
T Sudha, DJ Bharali, M Yalcin… - International journal …, 2017 - Taylor & Francis
The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is
chemically bonded via a linker to a poly (lactic-co-glycolic acid) nanoparticle that can …
chemically bonded via a linker to a poly (lactic-co-glycolic acid) nanoparticle that can …
Antibody-mediated enzyme therapeutics and applications in glycogen storage diseases
Z Zhou, GL Austin, R Shaffer, DD Armstrong… - Trends in molecular …, 2019 - cell.com
The use of antibodies as targeting molecules or cell-penetrating tools has emerged at the
forefront of pharmaceutical research. Antibody-directed therapies in the form of antibody …
forefront of pharmaceutical research. Antibody-directed therapies in the form of antibody …
Cathepsin B Nuclear Flux in a DNA-Guided “Antinuclear Missile” Cancer Therapy
F Cao, C Tang, X Chen, Z Tu, Y Jin, OM Turk… - ACS Central …, 2024 - ACS Publications
Some antinuclear antibodies (ANAs) bind extracellular nucleic acids released into tumor
environments and are pulled into the nuclei of live cancer cells through nucleoside salvage …
environments and are pulled into the nuclei of live cancer cells through nucleoside salvage …
Harnessing the therapeutic potential of 'Rogue'antibodies
JD Dimitrov - Trends in pharmacological sciences, 2020 - cell.com
Therapeutic antibodies have revolutionized modern medicine. At present, antibodies are
successfully used for treatment of diverse human diseases, ranging from cancer to viral …
successfully used for treatment of diverse human diseases, ranging from cancer to viral …
Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications
Z Rattray, V Dubljevic, NJW Rattray… - Biochemical and …, 2018 - Elsevier
A key challenge in the development of novel chemotherapeutics is the design of molecules
capable of selective toxicity to cancer cells. Antibodies have greater target specificity …
capable of selective toxicity to cancer cells. Antibodies have greater target specificity …
[HTML][HTML] PEGylated PLGA-based phase shift nanodroplets combined with focused ultrasound for blood brain barrier opening in rats
X Zhang, J Hu, G Zhao, N Huang, Y Tan, L Pi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Previous studies have shown that focused ultrasound (FUS) combined with systematic
administration of microbubbles (MBs) can open the blood brain barrier (BBB) locally …
administration of microbubbles (MBs) can open the blood brain barrier (BBB) locally …
[HTML][HTML] ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody
Z Rattray, G Deng, S Zhang, A Shirali, CK May… - JCI insight, 2021 - ncbi.nlm.nih.gov
The blood-brain barrier (BBB) prevents antibodies from penetrating the CNS and limits
conventional antibody-based approaches to brain tumors. We now show that ENT2, a …
conventional antibody-based approaches to brain tumors. We now show that ENT2, a …
[HTML][HTML] Inhibition of NETosis by a nuclear-penetrating anti-DNA autoantibody
X Chen, BJ Cuffari, V Dubljevic, A Shirali, J Zhou… - …, 2022 - journals.aai.org
Nuclear-penetrating anti-DNA autoantibodies have therapeutic potential as delivery agents
and in targeting DNA and the DNA damage response (DDR). Derivatives of such Abs have …
and in targeting DNA and the DNA damage response (DDR). Derivatives of such Abs have …