Central nervous system (CNS) disorders affect as many as 1.5 billion people globally. The
limited delivery of most imaging and therapeutic agents into the brain is a major challenge …

The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …

Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to
the development of organ-on-a-chip devices that can reproduce key functions of various …

Glioblastoma (GBM) is the most common and lethal type of malignant brain tumor in adults.
Currently, interventions are lacking, the median overall survival of patients with GBM is less …

The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

In some patients, COVID-19 can trigger neurological symptoms with unclear pathogenesis.
Here we describe a microphysiological system integrating alveolus and blood–brain barrier …

Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

The use of human cells for the construction of 3D organ models in vitro based on cell self-
assembly and engineering design has recently increased in popularity in the field of …

Abstract Parkinson's disease (PD), a neurodegenerative disease that shows a high
incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there is no …

The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …