[HTML][HTML] Role of animal models in biomedical research: a review
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …
Spine biomechanical testing methodologies: the controversy of consensus vs scientific evidence
Biomechanical testing methodologies for the spine have developed over the past 50 years.
During that time, there have been several paradigm shifts with respect to techniques. These …
During that time, there have been several paradigm shifts with respect to techniques. These …
[HTML][HTML] TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair
Q Wei, D Liu, G Chu, Q Yu, Z Liu, J Li, Q Meng… - Bioactive Materials, 2023 - Elsevier
Annulus fibrosus (AF) repair remains a challenge because of its limited self-healing ability.
Endogenous repair strategies combining scaffolds and growth factors show great promise in …
Endogenous repair strategies combining scaffolds and growth factors show great promise in …
[HTML][HTML] Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation
Y Zhao, C Qiu, W Wang, J Peng, X Cheng… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that
can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy …
can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy …
Intervertebral disc degeneration is associated with aberrant endplate remodeling and reduced small molecule transport
BG Ashinsky, ED Bonnevie… - Journal of Bone and …, 2020 - academic.oup.com
The intervertebral disc is the largest avascular structure in the body, and cells within the disc
rely on diffusive transport via vasculature located within the vertebral endplate to receive …
rely on diffusive transport via vasculature located within the vertebral endplate to receive …
[HTML][HTML] Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration
Y Peng, X Qing, H Shu, S Tian, W Yang… - Biomaterials …, 2021 - ncbi.nlm.nih.gov
Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …
and imposes heavy economic burden on the society, while it is greatly attributed to …
[HTML][HTML] Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model
Back pain is linked to intervertebral disc (IVD) degeneration, but clinical studies show the
relationship is complex. This study assessed whether males and females have distinct …
relationship is complex. This study assessed whether males and females have distinct …
Injectable nanostructured colloidal gels resembling native nucleus pulposus as carriers of mesenchymal stem cells for the repair of degenerated intervertebral discs
Intervertebral disc degeneration is strongly implicated as a cause of low-back pain. Stem cell-
based tissue engineering in treating intervertebral disc (IVD) degeneration recently obtained …
based tissue engineering in treating intervertebral disc (IVD) degeneration recently obtained …
[HTML][HTML] Single impact injury of vertebral endplates without structural disruption, initiates disc degeneration through Piezo1 mediated inflammation and metabolism …
Z Sun, X Zheng, S Li, B Zeng, J Yang, Z Ling, X Liu… - Spine, 2022 - journals.lww.com
Study Design. In vitro experimental study. Objective. To establish an axial impact injury
model of intervertebral disc (IVD) and to investigate if a single impact injury without endplate …
model of intervertebral disc (IVD) and to investigate if a single impact injury without endplate …
Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model
Background Vertebral endplate sclerosis and facet osteoarthritis have been documented in
animals and humans. However, it is unclear how these adjacent pathologies engage in …
animals and humans. However, it is unclear how these adjacent pathologies engage in …