Alcohol is a major contributor to global disease and a leading cause of preventable death,
causing approximately 88,000 deaths annually in the United States alone. Alcohol use …

Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …

Importance Although an estimated 30 million people meet criteria for alcohol use disorder
(AUD), few receive appropriate pharmacotherapy. A more personalized, symptom-specific …

Background The alcohol cue reactivity paradigm is increasingly used to screen medications
for the treatment of alcohol use disorder (AUD) and other substance use disorders. Yet, its …

Aberrant glucocorticoid signaling via glucocorticoid receptors (GR) plays a critical role in
alcohol use disorder (AUD). Acute alcohol withdrawal and protracted abstinence in …

Background Gabapentin is prescribed for seizures and pain and has efficacy for treating
alcohol use disorder (AUD) starting at doses of 900 milligrams per day (mg/d). Recent …

Compared to other medical disorders, including other brain diseases, the number of
medications approved for alcohol use disorder (AUD) is very small. Disulfiram, naltrexone …

Background Rodent models of high alcohol drinking offer opportunities to better understand
factors for alcohol use disorders (AUD) and test potential treatments. Selective breeding was …

The article discusses about the priority areas for improving medications development for
alcohol use disorder and promoting their routine use in clinical practice. During the past 25 …

Objective Gabapentin (GBP) and pregabalin (PGB) have been used to treat alcohol use
disorder (AUD) and alcohol withdrawal, but with inconsistent results. In this meta‐analysis …