Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …

Amyotrophic lateral sclerosis (ALS) involves progressive motor neuron loss, leading to
paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may …

Background We report the initial results from a phase I clinical trial for ALS. We transplanted
GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the …

Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …

The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

As in other neural systems, plasticity is a hallmark of the neural system controlling breathing.
One spinal mechanism of respiratory plasticity is phrenic long‐term facilitation (pLTF) …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that is
characterized by progressive degeneration of motor neurons in the cortex, brainstem and …

Intermittent hypoxia (IH) has been extensively studied during the last decade, primarily as a
surrogate model of sleep apnea. However, IH is a much more pervasive phenomenon in …