MicroRNA in cardiovascular biology and disease.
A Wojciechowska, A Braniewska… - … in Clinical & …, 2017 - search.ebscohost.com
MicroRNAs (miRNAs) are members of a non-coding RNA family. They act as negative
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …
Therapeutic targeting of microRNAs: current status and future challenges
Z Li, TM Rana - Nature reviews Drug discovery, 2014 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that have crucial
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …
Microneedle patch loaded with exosomes containing microRNA‐29b prevents cardiac fibrosis after myocardial infarction
J Yuan, H Yang, C Liu, L Shao, H Zhang… - Advanced …, 2023 - Wiley Online Library
Myocardial infarction (MI) is a cardiovascular disease that poses a serious threat to human
health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a …
health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a …
The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response
The mammalian heart has a remarkable regenerative capacity for a short period of time after
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …
Hippo pathway effector Yap promotes cardiac regeneration
The adult mammalian heart has limited potential for regeneration. Thus, after injury,
cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the …
cardiomyocytes are permanently lost, and contractility is diminished. In contrast, the …
Functional screening identifies miRNAs inducing cardiac regeneration
A Eulalio, M Mano, MD Ferro, L Zentilin, G Sinagra… - Nature, 2012 - nature.com
In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …
MicroRNAs in stress signaling and human disease
JT Mendell, EN Olson - Cell, 2012 - cell.com
Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …
Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression
The neonatal mammalian heart is capable of regeneration for a brief window of time after
birth. However, this regenerative capacity is lost within the first week of life, which coincides …
birth. However, this regenerative capacity is lost within the first week of life, which coincides …
Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family
ER Porrello, AI Mahmoud, E Simpson… - Proceedings of the …, 2013 - National Acad Sciences
We recently identified a brief time period during postnatal development when the
mammalian heart retains significant regenerative potential after amputation of the ventricular …
mammalian heart retains significant regenerative potential after amputation of the ventricular …
Advances in injectable hydrogel strategies for heart failure treatment
Heart failure (HF) affects 60 million people worldwide and has developed into a global
public health problem surpassing cancer and urgently needs to be solved. According to the …
public health problem surpassing cancer and urgently needs to be solved. According to the …