The human menopause transition and aging are each associated with an increase in a
variety of health risk factors including, but not limited to, cardiovascular disease …

In cardiovascular research, sex and gender have not typically been considered in research
design and reporting until recently. This has resulted in clinical research findings from which …

In females, menopause, the cessation of menstrual cycling, is associated with an increase in
risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the …

For many pathologies associated with aging, female patients present with higher morbidity
and more frequent adverse events from treatments compared to male patients. While …

Current rodent models of menopause fail to adequately recapitulate the menopause
transition. The intact aging model fails to achieve very low estrogen levels, and the …

The aim of this protocol is to provide a detailed description of male and female rodent
models of osteoporosis. In addition to indications on the methods of performing the surgical …

Fracture healing is impaired in aged and osteoporotic individuals. Because adequate
mechanical stimuli are able to increase bone formation, one therapeutical approach to treat …

The impact of sex and menopausal status in Alzheimer's disease remains understudied
despite increasing evidence of greater female risk, particularly in APOE4 carriers. Utilizing …

Osteoporosis, an imbalance in the bone-forming process mediated by osteoblasts and the
bone-resorbing function mediated by osteoclasts, is a bone degenerative disease prevalent …

Aims Premature ovarian failure (POF) is a phenomenon in which the ovaries fail before the
age of 40 years. Prior research has used a wide range of mouse models designed to reflect …