Human life within a narrow range: The lethal ups and downs of type I interferons
YJ Crow, JL Casanova - Science immunology, 2024 - science.org
The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …
The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization
RIG-I is an essential innate immune receptor that responds to infection by RNA viruses. The
RIG-I signaling cascade is mediated by a series of post-translational modifications, the most …
RIG-I signaling cascade is mediated by a series of post-translational modifications, the most …
Immune–epithelial cell cross‐talk enhances antiviral responsiveness to SARS‐CoV‐2 in children
VG Magalhães, S Lukassen, M Drechsler, J Loske… - EMBO …, 2023 - embopress.org
The risk of developing severe COVID‐19 rises dramatically with age. Schoolchildren are
significantly less likely than older people to die from SARS‐CoV‐2 infection, but the …
significantly less likely than older people to die from SARS‐CoV‐2 infection, but the …
[HTML][HTML] Activation of Immune Responses Through the RIG-I Pathway Using TRITC-Dextran Encapsulated Nanoparticles
H Baek, SW Yang, MK Kim, D Kim, C Lee… - Immune …, 2024 - pmc.ncbi.nlm.nih.gov
Pathogen-associated molecular patterns (PAMPs) are highly conserved motifs originating
from microorganisms that act as ligands for pattern recognition receptors (PRRs), which are …
from microorganisms that act as ligands for pattern recognition receptors (PRRs), which are …
RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response
TF Li, P Rothhaar, A Lang, O Gruenvogel, O Colasanti… - bioRxiv, 2023 - biorxiv.org
RNA-binding motif protein 39 (RBM39) is an RNA-binding protein involved in tumorigenesis,
cell metabolism, and development. Here, we performed a genome-wide CRISPR/Cas9 …
cell metabolism, and development. Here, we performed a genome-wide CRISPR/Cas9 …
Effective recognition of double-stranded RNA does not require activation of cellular inflammation
K Drazkowska, J Cieslicka, A Pastucha, L Markiewicz… - bioRxiv, 2024 - biorxiv.org
Excess double-stranded RNA (dsRNA) is present in the cytoplasm of human cells, usually
following viral infections. Recognition of dsRNAs activates innate immune pathways, leading …
following viral infections. Recognition of dsRNAs activates innate immune pathways, leading …
[引用][C] Immune–epithelial cell cross‐talk enhances antiviral responsiveness to SARS‐CoV‐2 in children
V Gonçalves Magalhães - Deutsche Nationalbibliothek