Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …

T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …

Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Due to the high prevalence and long incubation periods often without symptoms, the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals …

The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

Current success of immunotherapy in cancer has drawn attention to the subsets of TH cells
in the tumor which are critical for activation of anti-tumor response either directly by …

Senescent cell accumulation has been implicated in the pathogenesis of aging-associated
diseases, including cancer. The mechanism that prevents the accumulation of senescent …

Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …

Single-cell genomics technology has transformed our understanding of complex cellular
systems. However, excessive cost and a lack of strategies for the purification of newly …