The oxytocin receptor: from intracellular signaling to behavior
B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
[HTML][HTML] Toward a wiring diagram understanding of appetite control
ML Andermann, BB Lowell - Neuron, 2017 - cell.com
Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …
regulation. This goal is now being realized through the use of recent technological …
Genetics and epigenetics in obesity
K Rohde, M Keller, L la Cour Poulsen, M Blüher… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …
markedly increased over the last decades. Obesity maybe considered a heritable trait …
CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency
N Matharu, S Rattanasopha, S Tamura, L Maliskova… - Science, 2019 - science.org
INTRODUCTION Loss-of-function mutations in one gene copy can lead to reduced amounts
of protein and, consequently, human disease, a condition termed haploinsufficiency. It is …
of protein and, consequently, human disease, a condition termed haploinsufficiency. It is …
Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …
cause of numerous health complications and increased mortality. Being a complex and …
Neurobiology of food intake in health and disease
Under normal conditions, food intake and energy expenditure are balanced by a
homeostatic system that maintains stability of body fat content over time. However, this …
homeostatic system that maintains stability of body fat content over time. However, this …
[HTML][HTML] The hunger genes: pathways to obesity
AA Van der Klaauw, IS Farooqi - Cell, 2015 - cell.com
The global rise in the prevalence of obesity and associated co-morbidities such as type 2
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …
[HTML][HTML] Genetic and epigenetic causes of obesity
VV Thaker - Adolescent medicine: state of the art reviews, 2017 - ncbi.nlm.nih.gov
Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …
metagenomics and the environment. With the increasing access to high precision diagnostic …
Deconstruction of a neural circuit for hunger
Hunger is a complex behavioural state that elicits intense food seeking and consumption.
These behaviours are rapidly recapitulated by activation of starvation-sensitive AGRP …
These behaviours are rapidly recapitulated by activation of starvation-sensitive AGRP …
Rare genetic forms of obesity: clinical approach and current treatments in 2016
Obesity results from a synergistic relationship between genes and the environment. The
phenotypic expression of genetic factors involved in obesity is variable, allowing to …
phenotypic expression of genetic factors involved in obesity is variable, allowing to …