Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

Diabetes is a major threat to people's health and has become a burden worldwide. Current
drugs for diabetes have limitations, such as different drug responses among individuals …

MicroRNAs (miRNAs) are endogenous, small (18–23 nucleotides), non-coding RNA
molecules. They regulate the posttranscriptional expression of their target genes. MiRNAs …

A considerable number of drugs and/or their metabolites are excreted by the kidneys
through glomerular filtration and active renal tubule secretion via transporter proteins …

Background Variants in organic cation transporter (OCT) genes play a crucial role in
metformin pharmacokinetics and are critical for diabetes treatment. However, studies …

Metformin is one of the most prescribed drugs in type II diabetes (T2DM) which has recently
found new applications in the prevention and treatment of various illnesses, from metabolic …

Type 2 diabetes (T2D) represents one of the major health issues of this century. Despite the
availability of an increasing number of anti-hyperglycemic drugs, a significant proportion of …

Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by
elevated blood glucose. Multiple environmental and genetic factors can increase the risk of …

Background and aims Among anti-diabetic medications, metformin has been proven to be
the preferred initial pharmacologic agent for type 2 diabetes mellitus (T2DM) treatment …

The information derived from next generation sequencing technology allows the
identification of deregulated genes, gene mutations, epigenetic modifications, and other …