The use of photochemical transformations is a powerful strategy that allows for the formation
of a high degree of molecular complexity from relatively simple building blocks in a single …

Euphorbia Diterpenes: Isolation, Structure, Biological Activity, and Synthesis (2008–2012) |
Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In Chemical …

It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …

Terpenoids, also known as isoprenoids, are the most numerous and structurally diverse
natural products found in many plants. Several studies, in vitro, preclinical, and clinical have …

Abstract Ethnopharmacological relevance The genus Euphorbia (spurges, Euphorbiaceae)
is the third largest genus of flowering plants, with almost 2000 species. Its exceptional …

Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …

Ingenol is a diterpenoid with unique architecture and has derivatives possessing important
anticancer activity, including the recently Food and Drug Administration–approved Picato, a …

The diterpene compounds isolated from Euphorbiaceae and Thymelaeaceae species
possess a broad range of biological activities, including anti-HIV, tumor promotional …

Terpenoids are a very prominent class of natural compounds produced in diverse genera of
plants, fungi, algae and sponges. They gained significant pharmaceutical value since …

The first total synthesis of (+)-pedrolide, a tigliane-derived diterpenoid featuring an
unprecedented 5–5–6–6–3 carbon skeleton, is reported. Key to the approach is the …