The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to
the challenging field of virtual design and testing of technologies in a patient-specific …

Although blood-contacting medical devices are used widely, blood clot formation
(thrombosis) leads to device failure and potentially catastrophic adverse thrombotic events …

Protecting and promoting public health is the mission of the US Food and Drug
Administration (FDA). FDA's Center for Devices and Radiological Health (CDRH), which …

Mechanical circulatory support using ventricular assist devices is a common technique for
treating patients suffering from advanced heart failure. The latest generation of devices is …

Computational fluid dynamics (CFD) is widely used to simulate blood-contacting medical
devices. To be relied upon to inform high-risk decision making, however, model credibility …

Medical device manufacturers using computational modeling to support their device designs
have traditionally been guided by internally developed modeling best practices. A lack of …

Acute ischemic stroke (AIS) is a leading cause of mortality that occurs when an embolus
becomes lodged in the cerebral vasculature and obstructs blood flow in the brain. The …

Physics-based computational models of the cardiovascular system are increasingly used to
simulate hemodynamics, tissue mechanics, and physiology in evolving healthy and …

Purpose A credible computational fluid dynamics (CFD) model can play a meaningful role in
evaluating the safety and performance of medical devices. A key step towards establishing …

The present work develops hybrid multigrid methods for high-order discontinuous Galerkin
discretizations of elliptic problems, which are, for example, a key ingredient of …