Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …

In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and
translation in the cytoplasm imposes the requirement of transporting thousands of …

Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …

The association of genes with the nuclear pore complex (NPC) and nuclear transport factors
has been implicated in transcriptional regulation. We therefore examined the association of …

Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope,
thereby connecting the nuclear interior with the cytoplasm. Until recently, these …

The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host
immune responses through switching expression of variant surface proteins encoded by the …

Telomeres are nucleoprotein structures present at the ends of eukaryotic chromosomes that
play a central role in guarding the integrity of the genome by protecting chromosome ends …

Non-random positioning of chromosomal domains relative to each other and to nuclear
landmarks is a common feature of eukaryotic genomes. In particular, the distribution of DNA …

Dosage compensation in Drosophila is dependent on MSL proteins and involves
hypertranscription of the male X chromosome, which ensures equal X-linked gene …

The spatial arrangement of chromatin within the nucleus can affect reactions that occur on
the DNA and is likely to be regulated. Here we show that activation of INO1 occurs at the …