Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
Pathogenesis of acute graft‐versus‐host disease: from intestinal microbiota alterations to donor T cell activation
Acute graft‐versus‐host disease (aGVHD) is a major life‐threatening complication of
allogeneic haematopoietic cell transplantation (allo‐HCT). Here we discuss the aGVHD …
allogeneic haematopoietic cell transplantation (allo‐HCT). Here we discuss the aGVHD …
Strategies for enhancing and preserving anti-leukemia effects without aggravating graft-versus-host disease
YJ Chang, XY Zhao, XJ Huang - Frontiers in immunology, 2018 - frontiersin.org
Allogeneic stem cell transplantation (allo-SCT) is a curable method for the treatment of
hematological malignancies. In the past two decades, the establishment of haploidentical …
hematological malignancies. In the past two decades, the establishment of haploidentical …
The potential role of circRNA in tumor immunity regulation and immunotherapy
Z Xu, P Li, L Fan, M Wu - Frontiers in immunology, 2018 - frontiersin.org
Non-coding RNAs (ncRNAs) can be divided into circular non-coding RNAs (circRNAs) and
linear ncRNAs. ncRNAs exist in different cell types, including normal cells, tumor cells and …
linear ncRNAs. ncRNAs exist in different cell types, including normal cells, tumor cells and …
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Early-stage detection of leukemia is a critical determinant for successful treatment of the
disease and can increase the survival rate of leukemia patients. The factors limiting the …
disease and can increase the survival rate of leukemia patients. The factors limiting the …
MicroRNA-17 modulates regulatory T cell function by targeting co-regulators of the Foxp3 transcription factor
Regulatory T (Treg) cells are important in maintaining self-tolerance and immune
homeostasis. The Treg cell transcription factor Foxp3 works in concert with other co …
homeostasis. The Treg cell transcription factor Foxp3 works in concert with other co …
Microfluidic-templating alginate microgels crosslinked by different metal ions as engineered microenvironment to regulate stem cell behavior for osteogenesis
Y Zhang, C An, Y Zhang, H Zhang… - Materials Science and …, 2021 - Elsevier
Cell microenvironment is a collection of dynamic biochemical and biophysical cues which
functions as the key factor in determining cell behavior. Encapsulating single cell into …
functions as the key factor in determining cell behavior. Encapsulating single cell into …
The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease
Graft-versus-host disease (GVHD), manifesting as either acute (aGVHD) or chronic
(cGVHD), presents significant life-threatening complications following allogeneic …
(cGVHD), presents significant life-threatening complications following allogeneic …
The multifaceted interface between cytokines and microRNAs: an ancient mechanism to regulate the good and the bad of inflammation
S Garavelli, V De Rosa, P De Candia - Frontiers in immunology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are evolutionary conserved small non-coding RNA molecules that
affect gene expression by binding to target messenger RNAs and play a role in biological …
affect gene expression by binding to target messenger RNAs and play a role in biological …
MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice
Y Wu, S Schutt, K Paz, M Zhang… - Blood, The Journal …, 2018 - ashpublications.org
Chronic graft-versus-host disease (cGVHD) is characterized as autoimmune-like fibrosis and
antibody production mediated by pathogenic T cells and B cells. MicroRNA-17-92 (miR-17 …
antibody production mediated by pathogenic T cells and B cells. MicroRNA-17-92 (miR-17 …