Remarkable progress in bioengineering over the past two decades has enabled the
formulation of fundamental design principles for a variety of medical and non-medical …

Understanding the generation of complexity in living organisms requires the use of lineage
tracing tools at a multicellular scale. In this review, we describe the different multicolor …

The ability to discriminate sensory stimuli with overlapping features is thought to arise in
brain structures called expansion layers, where neurons carrying information about sensory …

The Drosophila type II neuroblast lineages present an attractive model to investigate the
neurogenesis and differentiation process as they adapt to a process similar to that in the …

Clonal selection and drift drive both normal tissue and cancer development. However, the
biological mechanisms and environmental conditions underpinning these processes remain …

Animals can discriminate myriad sensory stimuli but can also generalize from learned
experience. You can probably distinguish the favorite teas of your colleagues while still …

Mapping and determining the molecular identity of individual synapses is a crucial step
towards the comprehensive reconstruction of neuronal circuits. Throughout the history of …

Cellular barcoding methods offer the exciting possibility of 'infinite-pseudocolor'anatomical
reconstruction—ie, assigning each neuron its own random unique barcoded …

Recent advances in imaging technologies for generating large quantities of high-resolution
3D images, especially multispectral labeling technology such as Brainbow, permits …

The study of neuron morphology requires robust and comprehensive methods to quantify
the differences between neurons of different subtypes and animal species. Several software …