Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …

Background Therapeutic hypothermia significantly improves outcomes after moderate–
severe hypoxic-ischemic encephalopathy (HIE), but it is partially effective. Although …

Recently, a population of “immature” neurons generated prenatally, retaining immaturity for
long periods and finally integrating in adult circuits has been described in the cerebral …

Gene expression studies of human post-mortem brain tissue are useful for understanding
the pathogenesis of neurodegenerative disease. These studies rely on the assumption that …

Background: Alzheimer's disease (AD) is the most common form of dementia and is
characterized by a substantial reduction of neuroplasticity. Our previous work demonstrated …

Most biomedical research, including the neurosciences, is largely carried out using
laboratory rodents as animal models, yet differences are emerging with respect to humans …

The overarching aim of this thesis was to investigate the molecular mechanisms underlying
the spread of perinatal hypoxic-ischemic brain injury, particularly connexin hemichannels …