The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

Objective Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor
expressed in tissues with high oxidative activity that plays a central role in metabolism. In …

Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …

Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated
metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease …

Adipose triglyceride lipase (ATGL) has been discovered 14 years ago and revised our view
on intracellular triglyceride (TG) mobilization–a process termed lipolysis. ATGL initiates the …

Background & Aims Hepatic steatosis is a hallmark of non-alcoholic fatty liver disease
(NAFLD), a common comorbidity in type 2 diabetes mellitus (T2DM). The pathogenesis of …

While the physiological benefits of the fibroblast growth factor 21 (FGF21) hepatokine are
documented in response to fasting, little information is available on Fgf21 regulation in a …

The close association of obesity with an increased risk of metabolic diseases, such as
insulin resistance, type 2 diabetes, and nonalcoholic fatty liver disease, is now well …