Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Highlights•Cajal bodies have a definitive role in regulating the maturation of
snRNPs.•Numerous nuclear bodies contain scaffolding RNAs, including paraspeckles and …

It is not clear how spontaneous DNA double-strand breaks (DSBs) form and are processed
in normal cells, and whether they predispose to cancer-associated translocations. We show …

In the nucleus, there are several membraneless structures called nuclear bodies. Among
them, promyelocytic leukemia nuclear bodies (PML-NBs) are involved in multiple genome …

Telomeres, the terminal nucleoprotein structures of eukaryotic chromosomes, play
pleiotropic functions in cellular and organismal aging. Telomere length (TL) varies …

Oncogene addiction postulates that the survival and growth of certain tumor cells is
dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic …

The bulk of DNA damage caused by ionizing radiation (IR) is generally repaired within
hours, yet a subset of DNA lesions may persist even for long periods of time. Such persisting …

The promyelocytic leukemia (pml) gene product PML is a tumor suppressor localized mainly
in the nucleus of mammalian cells. In the cell nucleus, PML seeds the formation of …

Human herpesvirus 6B (HHV-6B) is a betaherpesvirus capable of integrating its genome
into the telomeres of host chromosomes. Until now, the cellular and/or viral proteins …

The spindle assembly checkpoint (SAC) prevents premature chromosome segregation by
inactivating the anaphase promoting complex/cyclosome (APC/C) until all chromosomes are …