Almost half a century after the first reports describing the limited replicative potential of
primary cells in culture, there is now overwhelming evidence for the existence of “cellular …

Reactive oxygen species are produced by all aerobic cells and are widely believed to play a
pivotal role in aging as well as a number of degenerative diseases. The consequences of …

Oncogenic ras can transform most immortal rodent cells to a tumorigenic state. However,
transformation of primary cells by ras requires either a cooperating oncogene or the …

Telomere erosion and subsequent dysfunction limits the proliferation of normal human cells
by a process termed replicative senescence. Replicative senescence is thought to suppress …

Human mesenchymal stem cells (hMSC) represent a promising cell-based therapy for a
number of degenerative conditions. Understanding the effect of aging on hMSCs is crucial …

The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell
cycle arrest, or senescence. To study the biological effects of altered p53 function, we …

Oncogenic Ras transforms immortal rodent cells to a tumorigenic state, in part, by
constitutively transmitting mitogenic signals through the mitogen-activated protein kinase …

Increased life expectancies have significantly increased the number of individuals suffering
from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and …

In humans, aging is inexorable. The progressive decrease in physiological capacity and the
reduced ability to respond to environmental stresses lead to increased susceptibility and …

The occurrence of DNA double strand breaks induces cell cycle arrest in mortal and
immortal human cells. In normal, mortal fibroblasts this block to proliferation is permanent. It …