Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Structural and transcriptional changes during early brain maturation follow fixed
developmental programs defined by genetics. However, whether this is true for functional …

Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …

Epilepsy affects 65 million people worldwide and entails a major burden in seizure-related
disability, mortality, comorbidities, stigma, and costs. In the past decade, important advances …

Current techniques for monitoring GABA (γ-aminobutyric acid), the primary inhibitory
neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop …

Epilepsy has been historically seen as a functional brain disorder associated with excessive
synchronization of large neuronal populations leading to a hypersynchronous state. Recent …

Abstract See Eissa and Schevon (doi: 10.1093/aww332) for a scientific commentary on this
article. Surgery can be a last resort for patients with intractable, medically refractory epilepsy …

Epileptic seizures represent dysfunctional neural networks dominated by excessive and/or
hypersynchronous activity. Recent progress in the field has outlined two concepts regarding …

Abstract See Lytton (doi: 10.1093/awx018) for a scientific commentary on this article. Neural
network oscillations are a fundamental mechanism for cognition, perception and …