The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their
established role in human cancer—overexpression of the large Maf genes promotes the …

Production and secretion of insulin from the β-cells of the pancreas is very crucial in
maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and …

J. Neurochem.(2010) 114, 810–819. Abstract Microglia plays an important role in many
neurodegenerative conditions. ATP leaked or released by damaged cells triggers microglial …

Nrf2 has gained great attention with respect to its pivotal role in cell and tissue protection.
Primarily defending cells against metabolic, xenobiotic and oxidative stress, Nrf2 is essential …

Multiple myeloma (MM) patients with the t (14; 16) translocation have a poor prognosis, and
unlike other molecular subgroups, their outcome has not improved with the introduction of …

The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are
involved in developmental, metabolic, and tumorigenic processes. Maf proteins are …

β-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions.
Pancreatic β-cell maturity and function are regulated by a variety of transcription factors that …

OBJECTIVE Islet β-cells loose their ability to synthesize insulin under diabetic conditions,
which is at least partially due to the decreased activity of insulin transcription factors such as …

A large number of mammalian transcription factors possess the evolutionary conserved
basic and leucine zipper domain (bZIP). The basic domain interacts with DNA while the …