Humans ascending to high altitude (HA) experience a reduction in arterial oxyhemoglobin
saturation and, as a result, arterial O2 content (C a O 2). As HA exposure extends, this …

This brief review addresses the regulation of cardiac output (Q) at rest and during
submaximal exercise in acute and chronic hypoxia. To preserve systemic O2 delivery in …

The purpose of this study was to examine the effects of acute normobaric (NH, decreased
FiO2) and hypobaric (HH, 4200 m ascent) hypoxia exposures compared to sea level …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

Over the last 100 years, high‐altitude researchers have amassed a comprehensive
understanding of the global cardiac responses to acute, prolonged and lifelong hypoxia …

The effects of heat and/or hypoxia have been well-documented in match-play data.
However, large match-to-match variation for key physical performance measures makes …

Key points We sought to determine the isolated and combined influence of hypovolaemia
and hypoxic pulmonary vasoconstriction on the decrease in left ventricular (LV) function and …

Aims The aim of this study was to analyse the underlying mechanisms of left and right
ventricular (LV and RV) functional alterations during several days in high-altitude hypoxia …

High-altitude exposure challenges the cardiovascular system to maintain oxygen delivery to
the mitochondria under conditions of hypoxic stress. Following acclimatisation (3–5 days) …

Chronic obstructive pulmonary disease (COPD) is associated with dynamic lung
hyperinflation (DH), increased pulmonary vascular resistance (PVR), and large increases in …