[HTML][HTML] The diagnosis and treatment of age-related macular degeneration

A Stahl - Deutsches Ärzteblatt International, 2020 - ncbi.nlm.nih.gov
Background Age-related macular degeneration (AMD) is thought to cause approximately 9%
of all cases of blindness worldwide. In Germany, half of all cases of blindness and high …

Diabetic macular edema: evidence-based management

DJ Browning, MW Stewart, C Lee - Indian journal of …, 2018 - journals.lww.com
Diabetic macular edema (DME) is the most common cause of vision loss in patients with
diabetic retinopathy with an increasing prevalence tied to the global epidemic in type 2 …

The role of osteopontin in microglia biology: current concepts and future perspectives

DD Rosmus, C Lange, F Ludwig, B Ajami, P Wieghofer - Biomedicines, 2022 - mdpi.com
The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Undertreatment of neovascular age-related macular degeneration after 10 years of anti-vascular endothelial growth factor therapy in the real world: the need for a …

J Monés, RP Singh, F Bandello, E Souied, X Liu… - …, 2020 - karger.com
Purpose: To assess the gap between visual acuity (VA) outcomes with anti-vascular
endothelial growth factor (anti-VEGF) therapies in clinical trials and real-world practice, and …

The impact of COVID-19 on intravitreal injection compliance

LM Wasser, Y Weill, K Brosh, I Magal, M Potter… - SN Comprehensive …, 2020 - Springer
Intravitreal injections (IVI) of anti–vascular endothelial growth factor (anti–VEGF) agents
have become the most prevalent intraocular procedure as they represent the major …

[HTML][HTML] VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal …

YZ Le - Vision research, 2017 - Elsevier
Müller glia (MG) are major retinal supporting cells that participate in retinal metabolism,
function, maintenance, and protection. During the pathogenesis of diabetic retinopathy (DR) …

The changing landscape for the management of patients with neovascular AMD: brolucizumab in clinical practice

I Pearce, W Amoaku, C Bailey, L Downey, R Gale… - Eye, 2022 - nature.com
Untreated neovascular age-related macular degeneration (nAMD) can lead to severe and
permanent visual impairment. The chronic nature of the disease can have a significant …

Pharmacological Management of Diabetic Macular Edema in Real‐Life Observational Studies

L Kodjikian, D Bellocq, T Mathis - BioMed Research …, 2018 - Wiley Online Library
Objectives of the Study. Summary of observational studies concerning the pharmacological
management of diabetic macular edema (DME). Methods. A literature review was conducted …

[HTML][HTML] BALATON and COMINO: phase III randomized clinical trials of Faricimab for retinal vein occlusion: study design and rationale

LO Hattenbach, F Abreu, P Arrisi, K Basu… - Ophthalmology …, 2023 - Elsevier
Purpose Dual inhibition of angiopoietin-2 and VEGF-A with faricimab (Vabysmo) offers
excellent visual acuity gains with strong durability in patients with diabetic macular edema …

[HTML][HTML] Transcriptomic characterization of human choroidal neovascular membranes identifies calprotectin as a novel biomarker for patients with age-related macular …

A Schlecht, S Boneva, M Gruber, P Zhang… - The American journal of …, 2020 - Elsevier
Recent studies deciphering the transcriptional profile of choroidal neovascularization (CNV)
in body donor eyes with neovascular age-related macular degeneration are limited by the …