The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR
NA Chapman, DJ Dupré… - Biochemistry and cell …, 2014 - cdnsciencepub.com
The apelin receptor (AR or APJ) is a class A (rhodopsin-like) G-protein-coupled receptor
with wide distribution throughout the human body. Activation of the AR by its cognate …
with wide distribution throughout the human body. Activation of the AR by its cognate …
Elucidating solution structures of cyclic peptides using molecular dynamics simulations
Protein–protein interactions are vital to biological processes, but the shape and size of their
interfaces make them hard to target using small molecules. Cyclic peptides have shown …
interfaces make them hard to target using small molecules. Cyclic peptides have shown …
Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist
[Pyr1] apelin-13 is an endogenous vasodilator and inotrope but is downregulated in
pulmonary hypertension and heart failure, making the apelin receptor an attractive …
pulmonary hypertension and heart failure, making the apelin receptor an attractive …
[HTML][HTML] Apelinergic system structure and function
Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …
The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders
The apelinergic pathway has been generating increasing interest in the past few years for its
potential as a therapeutic target in several conditions associated with the cardiovascular and …
potential as a therapeutic target in several conditions associated with the cardiovascular and …
Discovery of a competitive apelin receptor (APJ) antagonist
NJM Macaluso, SL Pitkin, JJ Maguire… - …, 2011 - Wiley Online Library
The apelin receptor (APJ) is a class AG‐protein‐coupled receptor (GPCR) and is a putative
target for the treatment of cardiovascular and metabolic diseases. Apelin‐13 (NH2 …
target for the treatment of cardiovascular and metabolic diseases. Apelin‐13 (NH2 …
Studying the structure and dynamics of biomolecules by using soluble paramagnetic probes
Characterisation of the structure and dynamics of large biomolecules and biomolecular
complexes by NMR spectroscopy is hampered by increasing overlap and severe …
complexes by NMR spectroscopy is hampered by increasing overlap and severe …
[HTML][HTML] Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking
G-protein coupled receptors (GPCRs) comprise a large family of membrane proteins with
rich functional diversity. Signaling through the apelin receptor (AR or APJ) influences the …
rich functional diversity. Signaling through the apelin receptor (AR or APJ) influences the …
Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands
Background Apelin is a peptide ligand for a class A G-protein coupled receptor called the
apelin receptor (AR or APJ) that regulates angiogenesis, the adipoinsular axis, and …
apelin receptor (AR or APJ) that regulates angiogenesis, the adipoinsular axis, and …
[HTML][HTML] Apela exhibits isoform-and headgroup-dependent modulation of micelle binding, peptide conformation and dynamics
Apela (also referred to as ELABELA and toddler) is a peptide hormone that activates the
apelin receptor (AR or APJ) to regulate cardiovascular system development and function …
apelin receptor (AR or APJ) to regulate cardiovascular system development and function …