Pathological and molecular features of glioblastoma and its peritumoral tissue

A D'Alessio, G Proietti, G Sica, BM Scicchitano - Cancers, 2019 - mdpi.com
Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At
present, GBMs are divided in primary and secondary on the basis of the mutational status of …

[HTML][HTML] The effects of metformin on autophagy

G Lu, Z Wu, J Shang, Z Xie, C Chen - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Metformin is the first-line option for treating newly diagnosed diabetic patients and also
involved in other pharmacological actions, including antitumor effect, anti-aging effect …

Recent advances in the molecular understanding of glioblastoma

FE Bleeker, RJ Molenaar, S Leenstra - Journal of neuro-oncology, 2012 - Springer
Glioblastoma is the most common and most aggressive primary brain tumor. Despite
maximum treatment, patients only have a median survival time of 15 months, because of the …

[HTML][HTML] MicroRNAs and the cell cycle

MJ Bueno, M Malumbres - Biochimica et Biophysica Acta (BBA)-Molecular …, 2011 - Elsevier
The control of cell proliferation by microRNAs (miRNAs) is well established and the
alteration of these small, non-coding RNAs may contribute to tumor development by …

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1*♦

TE Miller, K Ghoshal, B Ramaswamy, S Roy… - Journal of biological …, 2008 - ASBMB
We explored the role of microRNAs (miRNAs) in acquiring resistance to tamoxifen, a drug
successfully used to treat women with estrogen receptor-positive breast cancer. miRNA …

MicroRNAs in the pathogenesis of hepatocellular carcinoma: A review

A Morishita, K Oura, T Tadokoro, K Fujita, J Tani… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is one of the most frequently occurring
cancers, and the prognosis for late-stage HCC remains poor. A better understanding of the …

A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

M Kedde, M Van Kouwenhove, W Zwart… - Nature cell …, 2010 - nature.com
Key regulators of 3′ untranslated regions (3′ UTRs) are microRNAs and RNA-binding
proteins (RBPs),. The p27 tumour suppressor is highly expressed in quiescent cells, and its …

A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia

X Liu, Y Cheng, S Zhang, Y Lin, J Yang… - Circulation …, 2009 - Am Heart Assoc
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that
negatively regulate gene expression. Functionally, an individual miRNA is as important as a …

Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival

T Greither, LF Grochola, A Udelnow… - … journal of cancer, 2010 - Wiley Online Library
Pancreatic cancer is the eighth most common cancer and has an overall 5‐year survival rate
lower than 10%. Because of their ability to regulate gene expression, microRNAs can act as …

[HTML][HTML] Dysregulation of microRNAs in cancer: playing with fire

SA Melo, M Esteller - FEBS letters, 2011 - Elsevier
MicroRNAs [1] have emerged as key post-transcriptional regulators of gene expression,
involved in various physiological and pathological processes. It was found that several …