Bacterial sepsis and septic shock result from the overproduction of inflammatory mediators
as a consequence of the interaction of the immune system with bacteria and bacterial wall …

Periodontal disease is the major cause of adult tooth loss and is commonly characterized by
a chronic inflammation caused by infection of oral bacteria. Porphyromonas gingivalis (P …

The origin of soluble CD14 (sCD14) in the circulation is uncertain. To examine whether
CD14 could be an acute-phase protein (APP), the levels of sCD14, IL-6, and C-reactive …

Abstract IL-18, a potent IFN-γ-inducing cytokine, is expressed by various nonimmune cells
as well as macrophages, suggesting that it has important physiological and immunological …

The article details the role of Toll-like receptors in periodontal health and disease. Toll-like
receptors are proteins that recognize microbes breaching physical barriers like skin and …

Background Porphyromonas gingivalis is a major pathogen of periodontal disease that
affects a majority of adults worldwide. Increasing evidence shows that periodontal disease is …

Within the periodontium, the characteristic shift in microbial compositions that occurs during
the transition from health to disease has been well documented (132, 206). Concurrently, it …

SUMMARY CD14, a GPI-linked membrane protein, is a component of the
lipopolysaccharide (LPS) receptor complex, one of the pattern-recognizing receptors (PRR) …

Gingival fibroblasts produce proinflammatory cytokines in response to lipopolysaccharide
(LPS) from periodontopathic bacteria. Recently it has become evident that the human …

Since human gingival fibroblasts are the major cells in periodontal tissues, we hypothesized
that gingival fibroblasts are endowed with receptors for bacterial components, which induce …