Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Glutamate-gated AMPA receptors mediate the fast component of excitatory signal
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …
Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
We demonstrate an integrated approach to build, test, and refine a model of a cellular
pathway, in which perturbations to critical pathway components are analyzed using DNA …
pathway, in which perturbations to critical pathway components are analyzed using DNA …
Glutamate receptors in the mammalian central nervous system
S Ozawa, H Kamiya, K Tsuzuki - Progress in neurobiology, 1998 - Elsevier
Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core
N Armstrong, E Gouaux - Neuron, 2000 - cell.com
Crystal structures of the GluR2 ligand binding core (S1S2) have been determined in the apo
state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full …
state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full …
Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase
Modulation of postsynaptic AMPA receptors in the brain by phosphorylation may play a role
in the expression of synaptic plasticity at central excitatory synapses. It is known from …
in the expression of synaptic plasticity at central excitatory synapses. It is known from …
Pharmaceuticals that contain polycyclic hydrocarbon scaffolds
TP Stockdale, CM Williams - Chemical Society Reviews, 2015 - pubs.rsc.org
Numerous variations on structural motifs exist within pharmaceutical compounds that have
entered the clinic. These variations have amounted over many decades based on years of …
entered the clinic. These variations have amounted over many decades based on years of …
Mechanism of glutamate receptor desensitization
Ligand-gated ion channels transduce chemical signals into electrical impulses by opening a
transmembrane pore in response to binding one or more neurotransmitter molecules. After …
transmembrane pore in response to binding one or more neurotransmitter molecules. After …
Surface mobility of postsynaptic AMPARs tunes synaptic transmission
AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon
fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from …
fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from …
Structure of a glutamate-receptor ligand-binding core in complex with kainate
N Armstrong, Y Sun, GQ Chen, E Gouaux - Nature, 1998 - nature.com
Ionotropic glutamate receptors (iGluRs) mediate excitatory synaptic transmission in
vertebrates and invertebrates through ligand-induced opening of transmembrane ion …
vertebrates and invertebrates through ligand-induced opening of transmembrane ion …