Telomeres are nucleoprotein structures that cap the end of each chromosome arm and
function to maintain genome stability. The length of telomeres is known to shorten with each …

Aging is characterized by the functional decline of tissues and organs and increased risk of
aging-associated disorders, which pose major societal challenges and are a public health …

Centenarians are an excellent model to study the relationship between the gut microbiome
and longevity. To characterize the gut microbiome signatures of aging, we conducted a …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Aging is the most important risk factor for the development of major life-threatening diseases
such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging …

Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …

A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often
difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately …

Aging is associated with decreased bone mass and accumulation of bone marrow
adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived …

Individuals capable of reaching the extreme limit of human life such as centenarians are
characterized by an exceptionally healthy phenotype—that is, a low number of diseases, low …

Age is the single greatest risk factor for a wide range of diseases, and as the mean age of
human populations grows steadily older, the impact of this risk factor grows as well …