Cytomegalovirus: shape-shifting the immune system
G Picarda, CA Benedict - The Journal of Immunology, 2018 - journals.aai.org
Abstract Systems-based based approaches have begun to shed light on extrinsic factors that
contribute to immune system variation. Among these, CMV (HHV-5, a β-herpesvirus) …
contribute to immune system variation. Among these, CMV (HHV-5, a β-herpesvirus) …
New therapies for human cytomegalovirus infections
WJ Britt, MN Prichard - Antiviral research, 2018 - Elsevier
The recent approval of letermovir marks a new era of therapy for human cytomegalovirus
(HCMV) infections, particularly for the prevention of HCMV disease in hematopoietic stem …
(HCMV) infections, particularly for the prevention of HCMV disease in hematopoietic stem …
[HTML][HTML] Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children
A Ramaswamy, NN Brodsky, TS Sumida, M Comi… - Immunity, 2021 - cell.com
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious
complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 …
complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 …
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
LV Nobre, K Nightingale, BJ Ravenhill, R Antrobus… - Elife, 2019 - elifesciences.org
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating> 900
human proteins during viral replication and degrading≥ 133 proteins shortly after infection …
human proteins during viral replication and degrading≥ 133 proteins shortly after infection …
Long-read sequencing–a powerful tool in viral transcriptome research
Long-read sequencing (LRS) has become increasingly popular due to its strengths in de
novo assembly and in resolving complex DNA regions as well as in determining full-length …
novo assembly and in resolving complex DNA regions as well as in determining full-length …
Bright and early: Inhibiting human cytomegalovirus by targeting major immediate-early gene expression or protein function
CS Adamson, MM Nevels - Viruses, 2020 - mdpi.com
The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes
lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections …
lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections …
Functional profile of human cytomegalovirus genes and their associated diseases: a review
L Ye, Y Qian, W Yu, G Guo, H Wang, X Xue - Frontiers in microbiology, 2020 - frontiersin.org
The human cytomegalovirus (HCMV), whose genome is 235±1.9 kbp long, is a common
herpesvirus. However, the functions of many of its genes are still unknown. HCMV is closely …
herpesvirus. However, the functions of many of its genes are still unknown. HCMV is closely …
Human cytomegalovirus genomics and transcriptomics through the lens of next-generation sequencing: revision and future challenges
J Martí-Carreras, P Maes - Virus Genes, 2019 - Springer
The human cytomegalovirus (HCMV) genome was sequenced by hierarchical shotgun
almost 30 years ago. Over these years, low and high passaged strains have been …
almost 30 years ago. Over these years, low and high passaged strains have been …
Long-read sequencing uncovers a complex transcriptome topology in varicella zoster virus
Background Varicella zoster virus (VZV) is a human pathogenic alphaherpesvirus harboring
a relatively large DNA molecule. The VZV transcriptome has already been analyzed by …
a relatively large DNA molecule. The VZV transcriptome has already been analyzed by …
Alternative promoters drive human cytomegalovirus reactivation from latency
D Collins-McMillen, M Rak… - Proceedings of the …, 2019 - National Acad Sciences
Reactivation from latency requires reinitiation of viral gene expression and culminates in the
production of infectious progeny. The major immediate early promoter (MIEP) of human …
production of infectious progeny. The major immediate early promoter (MIEP) of human …