The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the
pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer's …

Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that
have seen a rising prevalence worldwide. Recent studies have indicated a possible link …

Mitochondria, far beyond their prominent role as cellular powerhouses, are complex cellular
organelles active as central metabolic hubs that are capable of integrating and controlling …

Dopamine regulates several functions, such as voluntary movements, spatial memory,
motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation …

Neurodegenerative disease (ND) incidence has recently increased due to improved life
expectancy. Alzheimer's (AD) or Parkinson's disease (PD) are the most prevalent NDs. Both …

Doxorubicin (DOX) is a chemotherapeutic agent that is linked with complications such as
cardiotoxicity and cognitive dysfunction, known as chemobrain. Chemobrain affects up to …

Peroxisome proliferator-activated receptors (PPARs) are a superfamily of nuclear
transcription receptors, consisting of PPARα, PPARγ, and PPARβ/δ, which are highly …

Recent progress in the structural and molecular pharmacological understanding of the
nuclear receptor, peroxisome proliferator-activated receptor gamma (hPPARγ)—a …

Functional impairments in the brain's insulin and insulin-like growth factor (IGF) signal
transduction networks are recognized mediators of dysregulated energy metabolism, a …

The recent success of disease‐modifying anti‐amyloid monoclonal antibodies in slowing
Alzheimer's disease (AD) symptoms has been an exciting step forward for the field. Despite …