Aim The aim of this review is to inform the reader on the latest developments in
epidemiology, diagnostics and management. Epidemiology Drug-resistant Tuberculosis (DR …

The World Health Organization's End TB Strategy prioritizes universal access to an early
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …

Drug-resistant tuberculosis is a serious global health threat. Bedaquiline (BDQ) is a
relatively new core drug, targeting the respiratory chain in Mycobacterium tuberculosis (Mtb) …

Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …

An in-house-developed target amplicon sequencing by next-generation sequencing
technology (TB-NGS) enables simultaneous detection of resistance-related mutations in …

The projected trajectory of multidrug resistant tuberculosis (MDR-TB) epidemics depends on
the reproductive fitness of circulating strains of MDR M. tuberculosis (Mtb). Previous efforts to …

Multidrug-resistant tuberculosis (MDR-TB) has historically required longer treatment
regimens that were associated with higher unfavorable outcomes and side effects rates …

The projected trajectory of multidrug resistant tuberculosis (MDR-TB) epidemics depends on
the reproductive fitness of circulating strains of MDR M. tuberculosis (Mtb). Previous efforts to …

Extract With recent expansion in the use of bedaquiline and limited access to accurate drug
susceptibility testing (DST), we read with concern of examples of the high prevalence of …

Background Bedaquiline is a core drug for treatment of rifampicin-resistant tuberculosis. Few
genomic variants have been statistically associated with bedaquiline resistance. Alternative …