The skin forms an effective barrier between the organism and the environment preventing
invasion of pathogens and fending off chemical and physical assaults, as well as the …

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute
and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury …

The strong societal urge to reduce the use of experimental animals, and the biological
differences between rodent and human skin, have led to the development of alternative …

Defects in several different connexins have been associated with several different diseases.
The most common of these is deafness, where a few mutations in connexin (Cx) 26 have …

Gap junctions allow the exchange of ions and small molecules between adjacent cells
through intercellular channels formed by connexin proteins, which can also form functional …

Melanoma cells interact with and depend on seemingly normal cells in their tumour
microenvironment to allow the acquisition of the hallmarks of solid cancer. In general, there …

The expression of multiple connexin (Cx) types in the epidermis, their differential expression
during wound closure and the association of skin pathology with specific Cx gene mutations …

Background CEDNIK (cerebral dysgenesis, neuropathy, ichthyosis and keratoderma)
syndrome is a rare genodermatosis which was shown 5 years ago in one family to be …

GJB2 mutations are major causes of autosomal recessive nonsyndromic hearing loss
(ARNSHL) in many populations. However, a few mutations have an ethnic-specific …

In the present review, we provide an overview of connexin expression during skin
development and remodeling in wound healing, and reflect on how loss-or gain-of-function …