Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …

Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …

Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in
evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 …

Hepatocyte Growth Factor (HGF, also known as Scatter Factor) is a powerful mitogen or
motility factor in different cells, acting through the tyrosine kinase receptor encoded by the …

Signaling pathways that mediate the normal functions of growth factors are commonly
subverted in cancer. Oncogenes identified by a variety of approaches have been shown to …

A set of growth arrest-specific genes (gas) whose expression is negatively regulated after
serum induction has previously been described (C. Schneider, RM King, and L. Philipson …

We have previously shown that Madin-Darby canine kidney (MDCK) epithelial cells grown in
collagen gels in the presence of fibroblasts orfibroblast-conditioned medium (CM) form …

Scatter Factor (SF) is a fibroblast‐secreted protein which promotes motility and matrix
invasion of epithelial cells. Hepatocyte Growth Factor (HGF) is a powerful mitogen for …

The met proto-oncogene is functionally linked with tumorigenesis and metastatic
progression. Validation of the receptor tyrosine kinase c-Met as a selective anticancer target …

Scatter factor (SF), a secretory protein of fibroblasts, dissociates and increases the motility of
epithelial cells and may be involved in cell migration processes during embryogenesis and …