The synaptic organization of layer 6 circuits reveals inhibition as a major output of a neocortical sublamina
The canonical cortical microcircuit has principally been defined by interlaminar excitatory
connections among the six layers of the neocortex. However, excitatory neurons in layer 6 …
connections among the six layers of the neocortex. However, excitatory neurons in layer 6 …
[HTML][HTML] The impact of neuron morphology on cortical network architecture
The neurons in the cerebral cortex are not randomly interconnected. This specificity in wiring
can result from synapse formation mechanisms that connect neurons, depending on their …
can result from synapse formation mechanisms that connect neurons, depending on their …
Cortical output is gated by horizontally projecting neurons in the deep layers
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian
neocortex. Here, we report the origins of the PTs' ability to respond to a broad range of …
neocortex. Here, we report the origins of the PTs' ability to respond to a broad range of …
Layer-specific inhibitory microcircuits of layer 6 interneurons in rat prefrontal cortex
C Ding, V Emmenegger, K Schaffrath… - Cerebral …, 2021 - academic.oup.com
GABAergic interneurons in different cortical areas play important roles in diverse higher-
order cognitive functions. The heterogeneity of interneurons is well characterized in different …
order cognitive functions. The heterogeneity of interneurons is well characterized in different …
Acquired parvalbumin‐selective interneuronopathy in the multiple‐hit model of infantile spasms: A putative basis for the partial responsiveness to vigabatrin analogs?
AM Katsarou, Q Li, W Liu, SL Moshé… - Epilepsia …, 2018 - Wiley Online Library
West syndrome, an age‐specific epileptic encephalopathy, manifests with infantile spasms
(IS) and impaired neurodevelopmental outcomes and epilepsy. The multiple‐hit rat model of …
(IS) and impaired neurodevelopmental outcomes and epilepsy. The multiple‐hit rat model of …
Layer 6A pyramidal cell subtypes form synaptic microcircuits with distinct functional and structural properties
D Yang, G Qi, C Ding, D Feldmeyer - Cerebral Cortex, 2022 - academic.oup.com
Neocortical layer 6 plays a crucial role in sensorimotor co-ordination and integration through
functionally segregated circuits linking intracortical and subcortical areas. We performed …
functionally segregated circuits linking intracortical and subcortical areas. We performed …
The impact of neuronal structure on cortical network architecture
Developmental programs that guide neurons and their neurites into specific subvolumes of
the mammalian neocortex give rise to lifelong constraints for the formation of synaptic …
the mammalian neocortex give rise to lifelong constraints for the formation of synaptic …
[PDF][PDF] A Theory for the Emergence of Neocortical Network Architecture
Developmental programs that guide neurons and their neurites into specific subvolumes of
the mammalian neocortex give rise to lifelong constraints for the formation of synaptic …
the mammalian neocortex give rise to lifelong constraints for the formation of synaptic …
Thalamus drives two complementary input strata of the neocortex in parallel
Sensory information enters the neocortex via thalamocortical axons that define the major
'input'layer 4. The same thalamocortical axons, however, additionally innervate the deep …
'input'layer 4. The same thalamocortical axons, however, additionally innervate the deep …
[PDF][PDF] Characterization of synaptic connections and cholinergic modulation of layer 6A microcircuitry in rat barrel cortex
D Yang - 2018 - scholar.archive.org
The mammalian neocortex is a multi-layered structure evolving from a sheet of proliferating
ventricular cells that progressively divide to form specific functional areas, such as prefrontal …
ventricular cells that progressively divide to form specific functional areas, such as prefrontal …