Toward a science of metabolic engineering

JE Bailey - Science, 1991 - science.org
Application of recombinant DNA methods to restructure metabolic networks can improve
production of metabolite and protein products by altering pathway distributions and rates …

Metabolic engineering

J Nielsen - Applied microbiology and biotechnology, 2001 - Springer
Metabolic engineering has developed as a very powerful approach to optimising industrial
fermentation processes through the introduction of directed genetic changes using …

Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes

JE Bailey, A Sburlati, V Hatzimanikatis… - Biotechnology and …, 1996 - Wiley Online Library
The classical method of metabolic engineering, identifying a rate‐determining step in a
pathway and alleviating the bottleneck by enzyme overexpression, has motivated much …

Bacterial hemoglobins and flavohemoglobins: versatile proteins and their impact on microbiology and biotechnology

AD Frey, PT Kallio - FEMS microbiology reviews, 2003 - academic.oup.com
In response to oxygen limitation or oxidative and nitrosative stress, bacteria express three
kinds of hemoglobin proteins: truncated hemoglobins (tr Hbs), hemoglobins (Hbs) and …

[HTML][HTML] Nonvertebrate hemoglobins: structural bases for reactivity

M Bolognesi, D Bordo, M Rizzi, C Tarricone… - Progress in biophysics …, 1997 - Elsevier
2.3. 1. Ascaris suum hemoglobin 45 2.3. 2. Chironomus thummi thummi erythrocruorin 47
2.3. 3. Lucina pectinata hemoglobin 49 2.3. 4. Aplysia limacina myoglobin 51 2.3. 5. Glycera …

Use of genetically engineered microorganisms (GEMs) for the bioremediation of contaminants

M Urgun-Demirtas, B Stark, K Pagilla - Critical reviews in …, 2006 - Taylor & Francis
This paper presents a critical review of the literature on the application of genetically
engineered microorganisms (GEMs) in bioremediation. The important aspects of using …

Recent applications of Vitreoscilla hemoglobin technology in bioproduct synthesis and bioremediation

BC Stark, KR Pagilla, KL Dikshit - Applied microbiology and biotechnology, 2015 - Springer
Since its first use in 1990 to enhance production of α-amylase in E. coli, engineering of
heterologous hosts to express the hemoglobin from the bacterium Vitreoscilla (VHb) has …

Intracellular expression of Vitreoscilla hemoglobin alters Escherichia coli energy metabolism under oxygen‐limited conditions

PT Kallio, D Jin KIM, PS Tsai… - European Journal of …, 1994 - Wiley Online Library
An earlier stoichiometric analysis of oxygen‐limited metabolism of Escherichia coli
expressing cloned Vitreoscilla hemoglobin (VHb) suggested improved efficiency of ATP …

Efficacy of supplementation of α-amylase-producing bacterial culture on the performance, nutrient use, and gut morphology of broiler chickens fed a corn-based diet

M Onderci, N Sahin, K Sahin, G Cikim, A Aydin… - Poultry Science, 2006 - Elsevier
A trial was conducted to evaluate the efficacy of an Escherichia coli strain producing α-
amylase of Bacillus stearothermophilus on growth performance, nutrient use, and the …

[HTML][HTML] Vitreoscilla hemoglobin: intracellular localization and binding to membranes

KW Hwang, M Raje, KJ Kim, BC Stark… - Journal of biological …, 2001 - ASBMB
The obligate aerobic bacterium, Vitreoscilla, synthesizes elevated quantities of a
homodimeric hemoglobin (VHb) under hypoxic growth conditions. Expression of VHb in …