Traumatic, tumoral, and infectious bone defects are common in clinics, and create a big
burden on patient's families and society. Calcium phosphate (CaP)-based biomaterials have …

Biomaterials have played an increasingly prominent role in the success of biomedical
devices and in the development of tissue engineering, which seeks to unlock the …

The immune microenvironment induced by biomaterials played vital roles in bone
regeneration. Hydroxyapatite (HA) and its ion-substituted derivates represent a large class …

Bone tissue engineering utilizes three critical elements–cells, scaffolds, and bioactive factors–
to recapitulate the bone tissue microenvironment, inducing the formation of new bone …

Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The
synthesis and fabrication of appropriate scaffold materials, their analytical characterization …

Bone is a complex biologic tissue, which is extremely relevant for various physiological
functions, in addition to movement, organ protection, and weight bearing. The repair of …

Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery.
The ideal treatment for such tissue loss is autografting, but donor sites are often limited …

Large-sized bone defect repair is a challenging task in orthopedic surgery. Porous scaffolds
with controlled release of growth factors have been investigated for many years. In this …

Natural bone is a highly vascularized tissue that relies on the vasculature for blood and
nutrients supply to maintain skeletal integrity. Inadequacy of neovascularization may …

The field of hybrid materials has grown so wildly in the last 30 years that writing a
comprehensive review has turned into an impossible mission. Yet, the need for a general …