Anti‐inflammatory activity of pyridazinones: A review
The pyridazinone core has emerged as a leading structure for fighting inflammation, with low
ulcerogenic effects. Moreover, easy functionalization of various ring positions of the …
ulcerogenic effects. Moreover, easy functionalization of various ring positions of the …
The effect of pyridazine compounds on the cardiovascular system
M Asif, A Singh, AA Siddiqui - Medicinal Chemistry Research, 2012 - Springer
Many natural as well as synthetic heterocylic compounds are known to have different
biological activities. The pyridazine moiety is an important structural feature of many …
biological activities. The pyridazine moiety is an important structural feature of many …
Synthesis and analgesic and anti-inflammatory activities 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal) hydrazone derivatives
In this study new 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted benzal)
hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents. The …
hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents. The …
Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives
WW WARDAKHAN, OME Abdel-Salam… - Acta …, 2008 - hrcak.srce.hr
Sažetak This study was aimed at the synthesis of fused benzothiophene derivatives
containing heterocyclic moiety. The reaction of the tetrahydrobenzo [b] thiophene derivatives …
containing heterocyclic moiety. The reaction of the tetrahydrobenzo [b] thiophene derivatives …
[HTML][HTML] Development of novel antibiotics derived from pyridazine: Synthesis, spectroscopic characterization, in vitro antimicrobial activity and molecular docking …
M Lahyaoui, M Filali, K Benamar, R Sghyar… - Results in …, 2024 - Elsevier
In light of the increasing antibiotic resistance, it is crucial to discover new antimicrobial
medications. Pyridazines are frequently investigated in research for the development of new …
medications. Pyridazines are frequently investigated in research for the development of new …
Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery
In spite of the availability of a large number of anti-inflammatory and analgesic agents,
fighting pain and inflammation remains a common problem. The current review article …
fighting pain and inflammation remains a common problem. The current review article …
A series of new hydrazone derivatives: Synthesis, molecular docking and anticholinesterase activity studies
Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to
be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is …
be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is …
A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies
Background The pyridazinone nucleus has been incorporated into a wide variety of
therapeutically interesting molecules to transform them into better drugs …
therapeutically interesting molecules to transform them into better drugs …
Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2H)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker
Novel twenty-three 3 (2 H)-pyridazinone derivatives were designed and synthesized based
on the chemical requirements related to the anti-proliferative effects previously …
on the chemical requirements related to the anti-proliferative effects previously …
General study of pyridazine compounds against cyclooxygenase enzyme and their relation with analgesic, anti-inflammatory and anti-arthritic activities
M Asif - Chronicles of Young Scientists, 2010 - go.gale.com
There is increased focus on developed non-steroidal anti-inflammatory drugs (NSAIDs)
containing a pyridazine nucleus. The NSAIDs are one of the most commonly used …
containing a pyridazine nucleus. The NSAIDs are one of the most commonly used …