Type 2 cytokines: mechanisms and therapeutic strategies
TA Wynn - Nature Reviews Immunology, 2015 - nature.com
Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-
13, which can either be host protective or have pathogenic activity. Type 2 immunity …
13, which can either be host protective or have pathogenic activity. Type 2 immunity …
[HTML][HTML] Targeting cell signaling in allergic asthma
SS Athari - Signal transduction and targeted therapy, 2019 - nature.com
Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …
A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant
YC Chang, CF Yang, YF Chen, CC Yang… - EMBO molecular …, 2022 - embopress.org
The emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
variants has altered the trajectory of the COVID‐19 pandemic and raised some uncertainty …
variants has altered the trajectory of the COVID‐19 pandemic and raised some uncertainty …
[HTML][HTML] Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA
damaging agents. However, the potential involvement of RNA sensors in DNA repair is …
damaging agents. However, the potential involvement of RNA sensors in DNA repair is …
Pulmonary siRNA delivery for lung disease: review of recent progress and challenges
Lung diseases are a leading cause of mortality worldwide and there exists urgent need for
new therapies. Approval of the first siRNA treatments in humans has opened the door for …
new therapies. Approval of the first siRNA treatments in humans has opened the door for …
[HTML][HTML] Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases
Airway and/or lung remodeling, involving exaggerated extracellular matrix (ECM) protein
deposition, is a critical feature common to pulmonary diseases including chronic obstructive …
deposition, is a critical feature common to pulmonary diseases including chronic obstructive …
SOCS3 and its role in associated diseases
Y Yin, W Liu, Y Dai - Human immunology, 2015 - Elsevier
Cell–cell communication depends on cytokine and growth factor network. Bound to their
receptors on the surface of target cell, these glycoproteins initiate a range of intracellular …
receptors on the surface of target cell, these glycoproteins initiate a range of intracellular …
KLF14 alleviated breast cancer invasion and M2 macrophages polarization through modulating SOCS3/RhoA/Rock/STAT3 signaling
J Chu, XC Hu, CC Li, TY Li, HW Fan, GQ Jiang - Cellular signalling, 2022 - Elsevier
Purpose To study the functions and underlying network of KLF14 in breast cancer invasion
and tumor-associated macrophages (TAMs). Methods The expressions of gene or protein …
and tumor-associated macrophages (TAMs). Methods The expressions of gene or protein …
[HTML][HTML] Nanoparticle delivery platforms for RNAi therapeutics targeting COVID-19 disease in the respiratory tract
Since December 2019, a pandemic of COVID-19 disease, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …
[HTML][HTML] Delivery of RNAi therapeutics to the airways—from bench to bedside
RNA interference (RNAi) is a potent and specific post-transcriptional gene silencing process.
Since its discovery, tremendous efforts have been made to translate RNAi technology into …
Since its discovery, tremendous efforts have been made to translate RNAi technology into …