Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in
a variety of medical settings such as wound closure, surgical sealants, regenerative …

Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

During development, both cells and tissues must acquire the correct shape to allow their
proper function. This is especially relevant in the nervous system, where the shape of …

Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …

In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix
are associated with cellular de-differentiation and with subsequent functional declines …

Over 300 billion of cells die every day in the human body, producing a large number of
endogenous apoptotic extracellular vesicles (apoEVs). Also, allogenic stem cell …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …